Multiple ways to regulate translation initiation in bacteria: Mechanisms, regulatory circuits, dynamics.
Fiche publication
Date publication
juillet 2015
Journal
Biochimie
Auteurs
Membres identifiés du Cancéropôle Est :
Dr SIMONETTI Angelita
Tous les auteurs :
Duval M, Simonetti A, Caldelari I, Marzi S
Lien Pubmed
Résumé
To adapt their metabolism rapidly and constantly in response to environmental variations, bacteria often target the translation initiation process, during which the ribosome assembles on the mRNA. Here, we review different mechanisms of regulation mediated by cis-acting elements, sRNAs and proteins, showing, when possible, their intimate connection with the translational apparatus. Indeed the ribosome itself could play a direct role in several regulatory mechanisms. Different features of the regulatory signals (sequences, structures and their positions on the mRNA) are contributing to the large variety of regulatory mechanisms. Ribosome heterogeneity, variation of individual cells responses and the spatial and temporal organization of the translation process add more layers of complexity. This hampers to define manageable set of rules for bacterial translation initiation control.
Mots clés
Bacterial translation initiation regulation, Regulatory proteins, Ribosome, cis-acting regulatory elements, sRNA
Référence
Biochimie. 2015 Jul;114:18-29