The multi-faceted regulation of nuclear tRNA gene transcription.
Fiche publication
Date publication
août 2019
Journal
IUBMB life
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MARÉCHAL-DROUARD Laurence
Tous les auteurs :
Hummel G, Warren J, Drouard L
Lien Pubmed
Résumé
Transfer RNAs are among the most ancient molecules of life on earth. Beyond their crucial role in protein synthesis as carriers of amino acids, they are also important players in a plethora of other biological processes. Many debates in term of biogenesis, regulation and function persist around these fascinating non-coding RNAs. Our review focuses on the first step of their biogenesis in eukaryotes, i.e. their transcription from nuclear genes. Numerous and complementary ways have emerged during evolution to regulate transfer RNA gene transcription. Here, we will summarize the different actors implicated in this process: cis-elements, trans-factors, genomic contexts, epigenetic environments and finally three-dimensional organization of nuclear genomes. © 2019 IUBMB Life, 2019 © 2019 IUBMB Life, 71(8):1099-1108, 2019.
Mots clés
RNA polymerase III-dependent transcription, evolution, gene expression and regulation, transfer RNAs
Référence
IUBMB Life. 2019 08;71(8):1099-1108