Alanine tRNAs Translate Environment Into Behavior in .
Fiche publication
Date publication
janvier 2020
Journal
Frontiers in cell and developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MARÉCHAL-DROUARD Laurence
Tous les auteurs :
Fernandes De Abreu DA, Salinas-Giegé T, Drouard L, Remy JJ
Lien Pubmed
Résumé
nematodes produce and maintain imprints of attractive chemosensory cues to which they are exposed early in life. Early odor-exposure increases adult chemo-attraction to the same cues. Imprinting is transiently or stably inherited, depending on the number of exposed generations. We show here that the Alanine tRNA (UGC) plays a central role in regulating chemo-attraction. Naive worms fed on tRNA (UGC) purified from odor-experienced worms, acquire odor-specific imprints. Chemo-attractive responses require the tRNA-modifying Elongator complex sub-units 1 () and 3 () genes. deletions impair chemo-attraction, which is fully restored by wild-type tRNA (UGC) feeding. A stably inherited decrease of odor-specific responses ensues from early odor-exposition of deletion mutants. tRNA (UGC) may adopt various chemical forms to mediate the cross-talk between innately-programmed and environment-directed chemo-attractive behavior.
Mots clés
behavior, chemoattraction, epitranscriptome, plasticity, tRNA
Référence
Front Cell Dev Biol. 2020 ;8:571359