Voltage-Dependent Anion Channels (VDACs): Overlapping and Specific Functions in Mitochondria.
Fiche publication
Date publication
avril 2020
Journal
Cells
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MARÉCHAL-DROUARD Laurence
Tous les auteurs :
Hemono M, Ubrig É, Azeredo K, Salinas-Giegé T, Drouard L, Duchêne AM
Lien Pubmed
Résumé
Voltage-dependent anion channels (VDACs) are essential components of the mitochondrial outer membrane. VDACs are involved in the exchange of numerous ions and molecules, from ATP to larger molecules such as tRNAs, and are supposed to adjust exchanges in response to cell signals and stresses. Four major VDACs have been identified in . The goal of this study was to explore the specific functions of these proteins, in particular, in tRNA import into mitochondria and stress response. The main results were: (i) VDACs appeared to differentially interact with tRNAs, and VDAC4 could be the major tRNA channel on the outer membrane, (ii) a VDAC3 mRNA isoform was found induced by different stresses, suggesting that VDAC3 might be specifically involved in early steps of stress response and (iii) an analysis of and mutant lines showed that VDAC3 and VDAC1 shared some, but not all functions. In conclusion, this work brings new knowledge on VDACs, which do not appear as interchangeable pores of the outer membrane and each VDAC has its own specificity.
Mots clés
OXPHOS, cold stress, heat stress, outer membrane, oxidative phosphorylation, oxidative stress, oxygen uptake, phosphate, proteome, salt, tRNA import
Référence
Cells. 2020 04 21;9(4):