The elastin peptide VGVAPG increases CD4 T-cell IL-4 production in patients with chronic obstructive pulmonary disease.
Fiche publication
Date publication
janvier 2021
Journal
Respiratory research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONICELLI Franck, Pr LE NAOUR Richard, Dr AUDONNET Sandra
Tous les auteurs :
Lemaire F, Audonnet S, Perotin JM, Gaudry P, Dury S, Ancel J, Lebargy F, Antonicelli F, Deslée G, Le Naour R
Lien Pubmed
Résumé
In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, we hypothesized that the pattern of T lymphocytes cytokine expression may be modulated by EP in COPD patients.
Mots clés
COPD, Cytokines, Elastin peptides, Flow cytometry, IL-4, T cells
Référence
Respir Res. 2021 Jan 13;22(1):14