Total gastrectomy for severe proton pump inhibitor-induced hypomagnesemia in a MEN1/Zollinger Ellison syndrome patient.
Fiche publication
Date publication
décembre 2020
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CADIOT Guillaume
Tous les auteurs :
Perrier M, Delemer B, Deguelte S, Legros V, Brixi H, Kianmanesh R, Cadiot G
Lien Pubmed
Résumé
We report here the first case of life-threatening hypomagnesemia in a Zollinger-Ellison syndrome patient with multiple endocrine neoplasia type 1 (MEN1) syndrome. The severe symptomatic hypomagnesemia proved to be due to proton pump inhibitors (PPIs), but withdrawal of PPIs led to early severe peptic complications despite a substitution by histamine H2-receptor antagonist therapy. Simultaneous management of life-threatening hypomagnesemia, severe gastric acid hypersecretion and MEN1-associated gastrinomas was complex. A total gastrectomy was performed in order to definitely preclude the use of PPIs in this frail patient who was not eligible for curative pancreatoduodenal resection.
Mots clés
Gastrinoma, Hypomagnesemia, Multiple endocrine neoplasia type 1 syndrome, Proton pump inhibitor, Total gastrectomy, Zollinger-Ellison syndrome
Référence
Pancreatology. 2020 Dec 7;: