Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.
Fiche publication
Date publication
décembre 2020
Journal
Brain, behavior, and immunity
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POISBEAU Pierrick
Tous les auteurs :
Gazzo G, Melchior M, Caussaint A, Gieré C, Lelièvre V, Poisbeau P
Lien Pubmed
Résumé
Early life stress is known to affect the development of the nervous system and its function at a later age. It increases the risk to develop psychiatric disorders as well as chronic pain and its associated affective comorbidities across the lifespan. GABAergic inhibition is important for the regulation of central function and related behaviors, including nociception, anxiety or social interactions, and requires low intracellular chloride levels. Of particular interest, the oxytocinergic (OTergic) system exerts potent anxiolytic, analgesic and pro-social properties and is known to be involved in the regulation of chloride homeostasis and to be impaired following early life stress.
Mots clés
anxiety, chloride homeostasis, neonatal maternal separation, oxytocin, pain, sociability
Référence
Brain Behav Immun. 2020 Dec 11;: