Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions.
Fiche publication
Date publication
mai 2016
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BIANCO Alberto
Tous les auteurs :
Chechetka SA, Yuba E, Kono K, Yudasaka M, Bianco A, Miyako E
Lien Pubmed
Résumé
Cancer is one of the primary causes of death worldwide. A high-precision analysis of biomolecular behaviors in cancer cells at the single-cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically- and near infrared light-triggered optical control method, based on nanorobotics, for the analyses of cellular functions. A new type of nanotransporters, composed of magnetic iron nanoparticles, carbon nanohorns, and liposomes, was synthesized for the spatiotemporal control of cellular functions in cells and mice. Our technology will help to create a new state-of-the-art tool for the comprehensive analysis of "real" biological molecular information at the single-cell level, and it may also help in the development of innovative cancer therapies.
Mots clés
carbon nanohorns, drug delivery systems, liposomes, magnetic nanoparticles, nanorobots
Référence
Angew Chem Int Ed Engl. 2016 05 23;55(22):6476-81