Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase.
Fiche publication
Date publication
septembre 2018
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BIANCO Alberto
Tous les auteurs :
Kurapati R, Mukherjee SP, Martín C, Bepete G, Vázquez E, Pénicaud A, Fadeel B, Bianco A
Lien Pubmed
Résumé
Biodegradability of graphene is one of the fundamental parameters determining the fate of this material in vivo. Two types of aqueous dispersible graphene, corresponding to single-layer (SLG) and few-layer graphene (FLG), devoid of either chemical functionalization or stabilizing surfactants, were subjected to biodegradation by human myeloperoxidase (hMPO) mediated catalysis. Graphene biodegradation was also studied in the presence of activated, degranulating human neutrophils. The degradation of both FLG and SLG sheets was confirmed by Raman spectroscopy and electron microscopy analyses, leading to the conclusion that highly dispersed pristine graphene is not biopersistent.
Mots clés
biodegradation, carbon nanomaterials, graphene, lungs, neutrophils
Référence
Angew Chem Int Ed Engl. 2018 09 3;57(36):11722-11727