Can the amniotic membrane be used to treat peripheral nerve defects? A review of literature.
Fiche publication
Date publication
septembre 2019
Journal
Hand surgery & rehabilitation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GINDRAUX Florelle
Tous les auteurs :
Bourgeois M, Loisel F, Obert L, Pluvy I, Gindraux F
Lien Pubmed
Résumé
Human amniotic membrane is currently being used in ophthalmology and dermatology applications. The objective of this review was to establish proof-of-concept for using amniotic membrane to treat peripheral nerve defects. We performed a search using: 1) PubMed with the keywords/MeSH terms: "amnion", "amniotic membrane", "angiogenesis", "anti-microbial", "characteristic", "chorion", "epithelialization", "fibrosis", "gap", "growth factors", "use", "nerve"; 2) the American clinical trials registry with "amniotic membrane"; 3) Lim Jeremy's book "A primer on amniotic membrane regenerative healing"; 4) the search engine Google. Our findings pointed to the amniotic membrane being a biodegradable and bioactive scaffold that contains many growth factors important for efficient nerve regeneration. Multiple animal studies and the single human clinical trial performed up to now have highlighted its role in preventing recurrence of perineural adhesions, reducing fibrosis, accelerating nerve repair and improving nerve function. Thus, the amniotic membrane has ideal properties for treating peripheral nerve injuries. It could very likely prevent neuroma formation. The best format would be a freeze-dried one containing the amnion and chorion layers in order to preserve all its growth factors, and facilitate its handling and storage in the operating room.
Mots clés
Amniotic membrane, Anti-fibrosant, Antifibrotic, Facteurs de croissances, Growth factors, Preuve de concept, Proof of concept, Scaffold, Support
Référence
Hand Surg Rehabil. 2019 09;38(4):223-232