Endowing carbon nanotubes with superparamagnetic properties: applications for cell labeling, MRI cell tracking and magnetic manipulations.
Fiche publication
Date publication
mai 2013
Journal
Nanoscale
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie, Dr FELDER-FLESCH Delphine, Dr MENARD-MOYON Cécilia, Dr BIANCO Alberto
Tous les auteurs :
Lamanna G, Garofalo A, Popa G, Wilhelm C, Bégin-Colin S, Felder-Flesch D, Bianco A, Gazeau F, Ménard-Moyon C
Lien Pubmed
Résumé
Coating of carbon nanotubes (CNTs) with magnetic nanoparticles (NPs) imparts novel magnetic, optical, and thermal properties with potential applications in the biomedical domain. Multi-walled CNTs have been decorated with iron oxide superparamagnetic NPs. Two different approaches have been investigated based on ligand exchange or "click chemistry". The presence of the NPs on the nanotube surface allows conferring magnetic properties to CNTs. We have evaluated the potential of the NP/CNT hybrids as a contrast agent for magnetic resonance imaging (MRI) and their interactions with cells. The capacity of the hybrids to magnetically monitor and manipulate cells has also been investigated. The NP/CNTs can be manipulated by a remote magnetic field with enhanced contrast in MRI. They are internalized into tumor cells without showing cytotoxicity. The labeled cells can be magnetically manipulated as they display magnetic mobility and are detected at a single cell level through high resolution MRI.
Mots clés
Cell Line, Tumor, Click Chemistry, methods, Contrast Media, chemistry, Humans, Magnetic Phenomena, Magnetic Resonance Imaging, Male, Materials Testing, Nanotubes, Carbon, chemistry, Neoplasms, diagnostic imaging, Radiography
Référence
Nanoscale. 2013 May 21;5(10):4412-21