The Cryo-immunologic effect: a therapeutic advance in the treatment of glioblastomas?
Fiche publication
Date publication
octobre 2020
Journal
Neuro-Chirurgie
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGI Afshin, Pr NOEL Georges, Dr GARNON Julien, Dr BURCKEL Hélène, Dr CEBULA Hélène, Pr PROUST François
Tous les auteurs :
Cebula H, Noel G, Garnon J, Todeschi J, Burckel H, DeMathelin M, Gangi A, Proust F
Lien Pubmed
Résumé
The immunotherapy of cerebral glioblastoma has become a hot topic. Immune checkpoint blockade antibodies have progressively acquired a role in the management of malignant tumors. A multimodal approach using surgery, radiotherapy, chemotherapy in combination with immunotherapy represent a potent weapon against glioblastomas. In parallel, clinical applications of cryotherapy - freezing tumors based on repetition of rapid freeze-slow thaw cycle - for various cancers such as skin, lung, breast, esophagus, hepatic, kidney, prostate and bone tumors were developed. The future immunomodulatory approaches might be combined with brain tumors cryoablation to increase the cryoimmune response.
Mots clés
Brain Oncology, Brain tumors, Cryotherapy, Cryothérapie, Imagerie guidée par IRM, Immunotherapie, Immunotherapy, MRI imaging guided, Oncologie cérébrale, Tumeurs cérébrales
Référence
Neurochirurgie. 2020 Oct 9;: