Clinical and biological features of haptoglobin phenotypes.
Fiche publication
Date publication
octobre 2020
Journal
Annales de biologie clinique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe, Dr OUDART Jean-Baptiste
Tous les auteurs :
Simon A, Schneider N, Gillery P, Oudart JB
Lien Pubmed
Résumé
Haptoglobin is a late positive acute phase protein of inflammation. Haptoglobin binds to free hemoglobin released from erythrocytes during intravascular hemolysis to form a complex which is removed shortly. Other properties like inhibition of oxidative stress and prostaglandin synthesis have been described. Three main phenotypes of haptoglobin have been identified: Hp1-1, Hp2-1, Hp2-2, which may have an impact in different diseases such as cardiovascular or infectious diseases. Haptoglobins of different phenotypes can be separated by capillary electrophoresis. They may induce a split of the alpha 2-globulin zone in the electrophoretic pattern. Hp1-1 and Hp2-1 phenotypes induce an important and a moderate split of the α2 globulin zone, respectively, whereas Hp2-2 does not. In vitro hemolysis and migration of a monoclonal component (i.e. immunoglobulin free light chain) may also induce a split of the alpha 2-globulin zone. In daily practice, Hp2-1 or Hp1-1 phenotypes could be notified in the electrophoresis report to alert the clinician about the possible physiopathological consequences.
Mots clés
electrophoresis, haemolysis, haptoglobin, phenotype
Référence
Ann Biol Clin (Paris). 2020 Oct 1;78(5):493-498