β1-Adrenergic Inhibition Improves Cardiac and Vascular Function in Experimental Septic Shock.
Fiche publication
Date publication
septembre 2015
Journal
Critical care medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARIE Pierre-Yves
Tous les auteurs :
Kimmoun A, Louis H, Al Kattani N, Delemazure J, Dessales N, Wei C, Marie PY, Issa K, Levy B
Lien Pubmed
Résumé
Preliminary experimental data suggest that selective β1-blockers may improve ex vivo cardiac function in animal sepsis. Currently, the effects of esmolol on in vivo cardiac function and on vascular function are unknown. The present study was designed to examine the effects of the β1-selective blocker esmolol on myocardial and vascular function in peritonitis-induced septic rats and to explore the inflammatory pathways involved in this process.
Mots clés
Adrenergic beta-1 Receptor Antagonists, pharmacology, Animals, Disease Models, Animal, Drug Therapy, Combination, Hemodynamics, Inflammation Mediators, metabolism, Male, NF-kappa B, biosynthesis, Nitric Oxide Synthase Type III, metabolism, Norepinephrine, pharmacology, Propanolamines, pharmacology, Rats, Rats, Wistar, Receptors, Adrenergic, alpha-1, biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, Shock, Septic, drug therapy, Up-Regulation, Vasoconstrictor Agents, pharmacology
Référence
Crit. Care Med.. 2015 Sep;43(9):e332-40