Baclofen destabilises breathing during sleep in healthy humans: a randomised, controlled, double-blind crossover trial.
Fiche publication
Date publication
septembre 2020
Journal
British journal of clinical pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHENUEL Bruno
Tous les auteurs :
Straus C, Teulier M, Morel S, Wattiez N, Hajage D, Giboin C, Charbit B, Dasque E, Bodineau L, Chenuel B, Straus N, Attali V, Similowski T
Lien Pubmed
Résumé
Periodic breathing is frequent in patients with severe heart failure. Apart from being an indicator of severity, periodic breathing has its own deleterious consequences (sleep-related oxygen desaturations, sleep fragmentation), which justifies attempts to correct it irrespective of the underlying disease. Animal models and human data suggest that baclofen can reconfigure respiratory central pattern generators. We hypothesised that baclofen, a GABA agonist, may thus be able to correct periodic breathing in humans.
Mots clés
Control of breathing, hypoxia, periodic breathing, sleep-disordered breathing
Référence
Br J Clin Pharmacol. 2020 Sep 28;: