Biologic agents for IBD: practical insights.
Fiche publication
Date publication
septembre 2015
Journal
Nature reviews. Gastroenterology & hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VUITTON Lucine, Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Danese S, Vuitton L, Peyrin-Biroulet L
Lien Pubmed
Résumé
Six biologic agents are currently approved for the treatment of IBD: four anti-TNF agents (infliximab, adalimumab, golimumab and certolizumab pegol) and two anti-integrin agents (natalizumab and vedolizumab). In Crohn's disease and ulcerative colitis refractory to standard medications, treatment choice among available biologic agents can be challenging. Several parameters should be taken into account to help physicians through the decision-making process, including the comparative effectiveness and long-term safety profile, availability and labelling in the prescriber's country, international guidelines, and cost, as well as patient preferences (such as the route of administration). Herein, we provide practical insights on the use of biologic agents in IBD. The results of head-to-head trials between biologic agents are eagerly awaited to guide decision-making regarding the choice of first-line biologic agents and to determine whether switching within the same drug class or swapping (switching out of the drug class) is preferable after primary or secondary loss of response to the first biologic agent. In the near future, treatment algorithms might evolve with the launch of new drugs (such as ustekinumab, tofacitinib and etrolizumab) and the increased use of biosimilars.
Mots clés
Algorithms, Biological Factors, therapeutic use, Colitis, Ulcerative, drug therapy, Crohn Disease, drug therapy, Drug Labeling, Forecasting, Humans, Patient Satisfaction, Practice Guidelines as Topic, Time Factors, Treatment Outcome
Référence
Nat Rev Gastroenterol Hepatol. 2015 Sep;12(9):537-45