Characterization of accessory genes in coronavirus genomes.
Fiche publication
Date publication
août 2020
Journal
Virology journal
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POCH Olivier, Dr THOMPSON Julie
Tous les auteurs :
Michel CJ, Mayer C, Poch O, Thompson JD
Lien Pubmed
Résumé
The Covid19 infection is caused by the SARS-CoV-2 virus, a novel member of the coronavirus (CoV) family. CoV genomes code for a ORF1a / ORF1ab polyprotein and four structural proteins widely studied as major drug targets. The genomes also contain a variable number of open reading frames (ORFs) coding for accessory proteins that are not essential for virus replication, but appear to have a role in pathogenesis. The accessory proteins have been less well characterized and are difficult to predict by classical bioinformatics methods.
Mots clés
Accessory genes, COVID-19, Circular code motifs, Coronavirus, ORF prediction, SARS-CoV, SARS-CoV-2
Référence
Virol. J.. 2020 Aug 27;17(1):131