[Ultrasmall nanoparticles for radiotherapy: AGuIX].
Fiche publication
Date publication
octobre 2015
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DETAPPE Alexandre
Tous les auteurs :
Lux F, Detappe A, Dufort S, Sancey L, Louis C, Carme S, Tillement O
Lien Pubmed
Résumé
Since twenty years, many nanoparticles based on high atomic number elements have been developed as radiosensitizers. The design of these nanoparticles is limited by the classical rules associated with the development of nanoparticles for oncology and by the specific ones associated to radiosensitizers, which aim to increase the effect of the dose in the tumor area and to spare the health tissues. For this application, systemic administration of nanodrugs is possible. This paper will discuss the development of AGuIX nanoparticles and will emphasize on this example the critical points for the development of a nanodrug for this application. AGuIX nanoparticles display hydrodynamic diameters of a few nanometers and are composed of polysiloxane and gadolinium chelates. This particle has been used in many preclinical studies and is evaluated for a further phase I clinical trial. Finally, in addition to its high radiosensitizing potential, AGuIX display MRI functionality and can be used as theranostic nanodrug for personalized medicine.
Mots clés
IRM, MRI, Nanoparticles, Nanoparticules, Radiotherapy, Radiothérapie, Theranostic, Théranostique
Référence
Cancer Radiother. 2015 Oct;19(6-7):508-14