Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses.
Fiche publication
Date publication
juillet 2020
Journal
European journal of medicinal chemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia, Dr DESAUBRY Laurent, Dr NEBIGIL-DESAUBRY Canan
Tous les auteurs :
Nebigil CG, Moog C, Vagner S, Benkirane-Jessel N, Smith DR, Désaubry L
Lien Pubmed
Résumé
Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Mots clés
COVID-19, Chikungunya virus, Coronavirus, Ebola virus, Natural products, Picornaviruses, Prohibitin, SARS-CoV-2, Zika virus, eIF4A
Référence
Eur J Med Chem. 2020 Jul 15;203:112653