Observation of hyperpositive non-linear effect in catalytic asymmetric organozinc additions to aldehydes.
Fiche publication
Date publication
juillet 2020
Journal
Chirality
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane
Tous les auteurs :
Geiger Y, Achard T, Maisse-François A, Bellemin-Laponnaz S
Lien Pubmed
Résumé
Asymmetric amplification is a phenomenon that is believed to play a key role in the emergence of homochirality in life. In asymmetric catalysis, theoretical and experimental models have been investigated to provide an understanding of how chiral amplification is possible, in particular based on non-linear effects. Interestingly, it has been proposed a quarter century ago that chiral catalysts, when not enantiopure might even be more enantioselective than their enantiopure counterparts. We show here that such hyperpositive non-linear effect in asymmetric catalysis is indeed possible. An in-depth study into the underlying mechanism was carried out, and the scheme we derive differs from the previous proposed models.
Mots clés
asymmetric catalysis, homogeneous catalysis, non-linear effect, zinc chemistry
Référence
Chirality. 2020 Jul 21;: