Pubertal outcomes of children transplanted with allogeneic stem cells after myeloablative total body irradiation or busulfan: Influence of age and sex is confirmed, while a role of chronic graft-versus-host disease in delayed puberty onset is revealed.
Fiche publication
Date publication
juillet 2020
Journal
Pediatric transplantation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POCHON Cécile
Tous les auteurs :
Weinhard S, Wiedemann A, Leheup B, Dalle JH, Lebon Labich B, Pochon C
Lien Pubmed
Résumé
Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long-term complications, especially gonadal dysfunction. Pubertal issues are less described than other post-HSCT sequelae in childhood.
Mots clés
female sex, graft-versus-host disease, hematopoietic stem cell transplantation, myeloablative conditioning regimen, pubertal development
Référence
Pediatr Transplant. 2020 Jul 23;:e13773