The low-expression programming of 11β-HSD2 mediates osteoporosis susceptibility induced by prenatal caffeine exposure in male offspring rats.
Fiche publication
Date publication
août 2020
Journal
British journal of pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MAGDALOU Jacques
Tous les auteurs :
Xiao H, Wu Z, Li B, Shangguan Y, Stoltz JF, Magdalou J, Chen L, Wang H
Lien Pubmed
Résumé
Prenatal caffeine exposure (PCE) can cause developmental toxicity of long bones in offspring, but the long-term effects and the underlying mechanism has not been fully clarified. Here, we investigated the effects of PCE peak bone mass accumulation and osteoporosis susceptibility in offspring and its intrauterine programming mechanism.
Référence
Br. J. Pharmacol.. 2020 Aug 5;: