High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
Fiche publication
Date publication
juillet 2020
Journal
Biochimie
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VITALE Nicolas
Tous les auteurs :
Dugail I, Amri EZ, Vitale N
Lien Pubmed
Résumé
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
Référence
Biochimie. 2020 Jul 7;: