Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders.
Fiche publication
Date publication
juillet 2020
Journal
Archives of cardiovascular diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Pr COTTIN Yves, Pr VERGELY Catherine
Tous les auteurs :
Rochette L, Meloux A, Zeller M, Cottin Y, Vergely C
Lien Pubmed
Résumé
The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and small humanin-like peptides (SHLPs). Humanin inhibits mitochondrial complex 1 activity and limits the level of oxidative stress in the cell. Data show that mitochondrial-derived peptides have a role in improving metabolic diseases, such as type 2 diabetes. Perhaps humanin can be used as a marker for mitochondrial function in cardiovascular disease or as a pharmacological strategy in patients with endothelial dysfunction. The goal of this review is to discuss the newly emerging functions of humanin, and its biological role in cardiovascular disorders.
Mots clés
Cardiovascular inflammation marker, Humanin, Humanine, Marqueur d’inflammation cardiovasculaire, Mitochondrial-derived peptides, Peptides mitochondriaux
Référence
Arch Cardiovasc Dis. 2020 Jul 14;: