A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.
Fiche publication
Date publication
juillet 2020
Journal
Breast cancer research : BCR
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LADOIRE Sylvain
Tous les auteurs :
Bonneau C, Eliès A, Kieffer Y, Bourachot B, Ladoire S, Pelon F, Hequet D, Guinebretière JM, Blanchet C, Vincent-Salomon A, Rouzier R, Mechta-Grigoriou F
Lien Pubmed
Résumé
Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as T1N0) have been rarely studied, as their prognosis is generally favorable. Nevertheless, up to 5% of luminal T1N0 BC patients relapse with distant metastases that ultimately prove fatal. The aim of our work was to identify the mechanisms involved in metastatic recurrence in these patients.
Mots clés
CDH11, Cadherin 11, Cancer-associated fibroblasts, Luminal breast cancer, Metastases, Stroma, TILs, Tumor infiltrating lymphocytes, Tumor micro-environment
Référence
Breast Cancer Res.. 2020 Jul 14;22(1):76