[Non-clear cell renal cell carcinoma: clinico-biological characteristics and therapeutic management except surgery].
Fiche publication
Date publication
juin 2020
Journal
Bulletin du cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BARTHELEMY Philippe, Dr LADOIRE Sylvain
Tous les auteurs :
Thouvenin J, Barthélémy P, Ladoire S
Lien Pubmed
Résumé
Non-clear cell renal cell carcinomas (nccRCC) account for nearly 25% of all kidney cancers, and represent a group of highly heterogeneous tumors both in terms of histological varieties and also oncogenic biological abnormalities. The clinical presentation as well as the prognosis of the patients is also very variable. Given the rarity of each tumor entity, there are very few clinical trials that have focused on a well-defined variety of non-clear cell cancer. So, it is difficult to interpret these studies, and therefore to develop clear recommendations for medical management of advanced disease. In this article, the main clinico-biological characteristics, as well as a summary of the clinical results obtained in patients with nccRCC cancer, except surgery, will be presented.
Mots clés
Carcinome papillaire, Carcinome rénal non, Immunotherapy, Immunothérapie, Papillary carcinoma, Renal carcinoma, Targeted therapies, Thérapies ciblées, no clear-cell, à cellules claires
Référence
Bull Cancer. 2020 Jun;107(5S):S56-S65