Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.
Fiche publication
Date publication
juin 2020
Journal
Archives of physiology and biochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KAHN Naim, Dr HICHAMI Aziz
Tous les auteurs :
Benbaibeche H, Hichami A, Oudjit B, Haffaf EM, Kacimi G, Koceïr EA, Khan NA
Lien Pubmed
Résumé
The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants. Our study included male obese, without co-morbidities ( = 29), and healthy participants ( = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood. miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants. We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.
Mots clés
CD36, adipocytokines, miR-146a, miR-21, obesity
Référence
Arch. Physiol. Biochem.. 2020 Jun 13;:1-6