Desensitization of the Cough Reflex Induced by Corticosteroids in Ovalbumin-Sensitized Rabbits During Artificial Limb Exercise.
Fiche publication
Date publication
janvier 2020
Journal
Frontiers in physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHENUEL Bruno, Pr POUSSEL Mathias
Tous les auteurs :
Valentin S, Chenuel B, Demoulin-Alexikova S, Demoulin B, Gérard D, Foucaud L, Poussel M
Lien Pubmed
Résumé
Cough is a major symptom frequently experienced during exercise, mainly in asthmatic patients. Inhaled glucocorticoids represent the keystone treatment in the management of asthma, but little is known about interactions between cough and exercise, especially in controlled patients. During exercise, cough reflex (CR) appears downregulated in healthy animal models whereas a lack of desensitization of CR has been shown in ovalbumin-sensitized animal models, mimicking asthmatic disease.
Mots clés
airway inflammation, asthma, corticosteroids, cough reflex, exercise
Référence
Front Physiol. 2020 ;11:466