Design of the DRAGET Study: a multicentre controlled diagnostic study to assess the detection of acute rejection in patients with heart transplant by means of T2 quantification with MRI in comparison to myocardial biopsies.
Fiche publication
Date publication
octobre 2015
Journal
BMJ open
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FELBLINGER Jacques
Tous les auteurs :
Bonnemains L, Cherifi A, Girerd N, Odille F, Felblinger J
Lien Pubmed
Résumé
Patients with heart transplant are screened for silent graft rejection by recurrent endomyocardial biopsies. MRI can detect the presence of oedema non-invasively by quantitatively measuring changes of the transverse relaxation time T2 in the myocardium. Several monocentric studies have shown that T2 quantification could help detect graft rejection in a less invasive way. DRAGET is a national multicentre diagnostic study designed to prove that T2 quantification by MRI can detect graft rejection.
Mots clés
Adolescent, Adult, Biopsy, Edema, Graft Rejection, diagnosis, Heart, Heart Transplantation, Humans, Magnetic Resonance Imaging, methods, Myocardium, pathology, Prognosis
Référence
BMJ Open. 2015 Oct 29;5(10):e008963