Macropolycytes: Severe stress time for neutrophils.
Fiche publication
Date publication
mai 2020
Journal
Morphologie : bulletin de l'Association des anatomistes
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LESESVE Jean-François, Pr BROSEUS Julien
Tous les auteurs :
Lesesve JF, Thomas B, Broséus J, Bain BJ
Lien Pubmed
Résumé
Macropolycytes are giant neutrophils found in a variety of benign and neoplastic conditions. Since megaloblastic anaemia is one of the recognised causes of macropolycytes, other blood film features of megaloblastic anaemia should be sought when they harbor hypersegmented nuclei. When they are hypolobulated and hypogranular, the occurrence of a myelodysplastic syndrome must be investigated. Finding macropolycytes in the context of a nonspecific reactive granulopoiesis is more questionable but is often associated with stressed myelopoiesis and/or granulocyte colony-stimulating factor therapy.
Mots clés
Giant neutrophils, Macropolycytes, Megaloblastic anemia, Myelodysplastic syndrome, Stressed hematopoïesis
Référence
Morphologie. 2020 May 11;: