Lineage specification in the fly nervous system and evolutionary implications.
Fiche publication
Date publication
septembre 2013
Journal
Cell cycle (Georgetown, Tex.)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GIANGRANDE Angela, Dr CATTENOZ Pierre
Tous les auteurs :
Cattenoz PB, Giangrande A
Lien Pubmed
Résumé
Over the last decades, it has become clear that glia are multifunctional and plastic cells endowed with key regulatory roles. They control the response to developmental and/or pathological signals, thereby affecting neural proliferation, remodeling, survival, and regeneration. It is, therefore, important to understand the biology of these cells and the molecular mechanisms controlling their development/activity. The fly community has made major breakthroughs by characterizing the bases of gliogenesis and function. Here we describe the regulation and the role of the fly glial determinant. Then, we discuss the impact of the determinant in cell plasticity and differentiation. Finally, we address the conservation of this pathway across evolution.
Mots clés
Animals, Biological Evolution, Cell Lineage, Drosophila, cytology, Nervous System, cytology, Neuroglia, cytology, Stem Cells, cytology
Référence
Cell Cycle. 2013 Sep;12(17):2753-9