Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.
Fiche publication
Date publication
novembre 2015
Journal
Nano letters
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DETAPPE Alexandre
Tous les auteurs :
Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI
Lien Pubmed
Résumé
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.
Mots clés
Gold nanoparticles, endothelial radiation damage, image-guided radiation therapy, tumor vascular disruption
Référence
Nano Lett.. 2015 Nov 11;15(11):7488-96