Senescence and Cancer: Role of Nitric Oxide (NO) in SASP.
Fiche publication
Date publication
mai 2020
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali, Pr PAUL Catherine, Dr PLENCHETTE Stéphanie
Tous les auteurs :
Mabrouk N, Ghione S, Laurens V, Plenchette S, Bettaieb A, Paul C
Lien Pubmed
Résumé
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the senescent phenotypes and, more precisely, on the senescence-associated secretory phenotype (SASP). In this review, we discuss the modulatory effect of nitric oxide (NO) in SASP and the possible benefits of the use of NO donors or iNOS inducers in combination with senotherapy in cancer treatment.
Mots clés
SASP, cancer treatments, nitric oxide
Référence
Cancers (Basel). 2020 May 2;12(5):