Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip.
Fiche publication
Date publication
avril 2020
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr LUPBERGER Joachim
Tous les auteurs :
Goto K, Roca Suarez AA, Wrensch F, Baumert TF, Lupberger J
Lien Pubmed
Résumé
Chronic infection with hepatitis C virus (HCV) is a major cause of hepatocellular carcinoma (HCC). Novel treatments with direct-acting antivirals achieve high rates of sustained virologic response; however, the HCC risk remains elevated in cured patients, especially those with advanced liver disease. Long-term HCV infection causes a persistent and accumulating damage of the liver due to a combination of direct and indirect pro-oncogenic mechanisms. This review describes the processes involved in virus-induced disease progression by viral proteins, derailed signaling, immunity, and persistent epigenetic deregulation, which may be instrumental to develop urgently needed prognostic biomarkers and as targets for novel chemopreventive therapies.
Mots clés
HCC, HCV, clinical impact, epigenetics, signaling, tumor immunity
Référence
Int J Mol Sci. 2020 Apr 26;21(9):