Efficacy of anti-TNFα drugs in patients with stricturing Crohn's disease.
Fiche publication
Date publication
avril 2020
Journal
Expert review of gastroenterology & hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
D'Amico F, Pugliese N, Peyrin-Biroulet L, Danese S
Lien Pubmed
Résumé
: Half of Crohn's disease patients develops stenosis around 20 years after the disease onset. For a long time, surgery has been the only therapeutic approach for strictures. The introduction of anti-TNFα could be revolutionary in the management of these patients due to their potential role in stenoses' treatment. The aim of our work was to summarize efficacy data of anti-TNFα drugs in stricturing CD patients.: Several case series and observational studies have shown that infliximab and adalimumab are effective in determining improvement and remission of stenosis in CD patients in both clinical trials and clinical practice. The injection of intralesional infliximab could be a valid alternative in patients not responding to systemic therapy.: Despite the promising literature data, the low level of evidence and the heterogeneity of the available studies do not allow to draw definitive conclusions on the use of TNFα inhibitors for the treatment of strictures. Further prospective randomized studies are needed to confirm and validate this therapeutic approach.
Mots clés
Crohn’s disease, anti-TNFα, efficacy, strictures
Référence
Expert Rev Gastroenterol Hepatol. 2020 Apr 30;: