Stem cells: a promising source for vascular regenerative medicine.
Fiche publication
Date publication
décembre 2014
Journal
Stem cells and development
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MENU Patrick, Dr KERDJOUDJ Halima
Tous les auteurs :
Rammal H, Harmouch C, Lataillade JJ, Laurent-Maquin D, Labrude P, Menu P, Kerdjoudj H
Lien Pubmed
Résumé
The rising and diversity of many human vascular diseases pose urgent needs for the development of novel therapeutics. Stem cell therapy represents a challenge in the medicine of the twenty-first century, an area where tissue engineering and regenerative medicine gather to provide promising treatments for a wide variety of diseases. Indeed, with their extensive regeneration potential and functional multilineage differentiation capacity, stem cells are now highlighted as promising cell sources for regenerative medicine. Their multilineage differentiation involves environmental factors such as biochemical, extracellular matrix coating, oxygen tension, and mechanical forces. In this review, we will focus on human stem cell sources and their applications in vascular regeneration. We will also discuss the different strategies used for their differentiation into both mature and functional smooth muscle and endothelial cells.
Mots clés
Animals, Humans, Neovascularization, Physiologic, Regenerative Medicine, methods, Stem Cell Transplantation, methods, Stem Cells, classification
Référence
Stem Cells Dev.. 2014 Dec;23(24):2931-49