Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting.
Fiche publication
Date publication
mars 2017
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FEUGEAS Jean-Paul
Tous les auteurs :
Romero M, Gapihan G, Castro-Vega LJ, Acevedo A, Wang L, Li ZW, El Bouchtaoui M, Di Benedetto M, Ratajczak P, Feugeas JP, Thieblemont C, Saavedra C, Janin A
Lien Pubmed
Résumé
Primary mediastinal large B-cell lymphoma (PMBL) shares pathological features with diffuse large B-cell lymphoma (DLBCL), and molecular features with classical Hodgkin lymphoma (cHL). The miR-17~92 oncogenic cluster, located at chromosome 13q31, is a region that is amplified in DLBCL.
Mots clés
FOXP1, bioinformatics approach, diffuse large B-cell lymphoma, miR-17-92 oncogenic cluster, primary mediastinal large B-cell lymphoma
Référence
Oncotarget. 2017 Mar 7;8(10):16243-16258