Increased risk of brain metastases in women with breast cancer and p16 expression in metastatic lymph-nodes.
Fiche publication
Date publication
juin 2017
Journal
Oncotarget
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FEUGEAS Jean-Paul
Tous les auteurs :
Furet E, El Bouchtaoui M, Feugeas JP, Miquel C, Leboeuf C, Beytout C, Bertheau P, Le Rhun E, Bonneterre J, Janin A, Bousquet G
Lien Pubmed
Résumé
Metastatic breast cancer is a leading cause of mortality in women, partly on account of brain metastases. However, the mechanisms by which cancer cells cross the blood-brain barrier remain undeciphered. Most molecular studies predicting metastatic risk have been performed on primary breast cancer samples. Here we studied metastatic lymph-nodes from patients with breast cancers to identify markers associated with the occurrence of brain metastases.
Mots clés
brain metastases, breast cancer, p16
Référence
Oncotarget. 2017 Jun 6;8(23):37332-37341