Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis.
Fiche publication
Date publication
juillet 2017
Journal
Breast cancer research and treatment
Auteurs
Membres identifiés du Cancéropôle Est :
Pr WEMMERT Cédric
Tous les auteurs :
Schaadt NS, Alfonso JCL, Schönmeyer R, Grote A, Forestier G, Wemmert C, Krönke N, Stoeckelhuber M, Kreipe HH, Hatzikirou H, Feuerhake F
Lien Pubmed
Résumé
To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis. We consider potential immune cell variations due to the menstrual cycle and oral contraceptives in non-neoplastic mammary gland tissue.
Mots clés
Digital pathology, Hormonal fluctuations, Lymphocytic lobulitis, Menstrual cycle, Object-based image analysis, Oncoimmunology
Référence
Breast Cancer Res. Treat.. 2017 Jul;164(2):305-315