Tailoring the immune response to nutrients' availability.
Fiche publication
Date publication
avril 2020
Journal
The FEBS journal
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GIANGRANDE Angela, Dr CATTENOZ Pierre
Tous les auteurs :
Cattenoz PB, Giangrande A
Lien Pubmed
Résumé
The development and the maintenance of an efficient immune system represents a considerable metabolic investment for the organism. Ramond et al. have characterized a new molecular and cellular pathway, inhibiting the immune system in poor diet conditions in the Drosophila larva. Low nutrient conditions lead to the secretion of the adipokine NimB5 by the fat body, which inhibits the proliferation of the immune cells, hence preventing the exhaustion of the resources. Comment on: https://doi.org/10.1111/febs.15237.
Mots clés
Drosophila , NimB5, adipokine, fat body, hemocyte
Référence
FEBS J.. 2020 Apr 13;: