Lipids Nutrients in Parkinson and Alzheimer's Diseases: Cell Death and Cytoprotection.
Fiche publication
Date publication
avril 2020
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard
Tous les auteurs :
Nury T, Lizard G, Vejux A
Lien Pubmed
Résumé
Neurodegenerative diseases, particularly Parkinson's and Alzheimer's, have common features: protein accumulation, cell death with mitochondrial involvement and oxidative stress. Patients are treated to cure the symptoms, but the treatments do not target the causes; so, the disease is not stopped. It is interesting to look at the side of nutrition which could help prevent the first signs of the disease or slow its progression in addition to existing therapeutic strategies. Lipids, whether in the form of vegetable or animal oils or in the form of fatty acids, could be incorporated into diets with the aim of preventing neurodegenerative diseases. These different lipids can inhibit the cytotoxicity induced during the pathology, whether at the level of mitochondria, oxidative stress or apoptosis and inflammation. The conclusions of the various studies cited are oriented towards the preventive use of oils or fatty acids. The future of these lipids that can be used in therapy/prevention will undoubtedly involve a better delivery to the body and to the brain by utilizing lipid encapsulation.
Mots clés
lipids nutrients, apoptosis, oxidative stress, mitochondria, synuclein, amyloid, Tau, Parkinson’s disease, Alzheimer’s disease
Référence
Int J Mol Sci. 2020 Apr 3;21(7):