The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?
Fiche publication
Date publication
avril 2020
Journal
Autophagy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUITTAUT Michaël, Dr FRAICHARD Annick, Dr DESPOUY Gilles
Tous les auteurs :
Jacquet M, Guittaut M, Fraichard A, Despouy G
Lien Pubmed
Résumé
The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles from autophagy induction to autophagosome-lysosome fusion and have been described to play a role during cancer progression. Indeed, GABARAPs are described to be downregulated in cancers, and high expression has been linked to a good prognosis. Regarding LC3s, their expression does not correlate to a particular tumor type or stage. The involvement of Atg8-family proteins during cancer, therefore, remains unclear, and it appears that their anti-tumor role may be associated with their implication in selective protein degradation by autophagy but might also be independent, in some cases, of their conjugation to autophagosomes. In this review, we will then focus on the involvement of GABARAP and LC3 subfamilies during autophagy and cancer and highlight the similarities but also the differences of action of each subfamily member.
Mots clés
Atg8, GABARAP, GABARAPL1, GABARAPL2, LC3, autophagy, cancer
Référence
Autophagy. 2020 Apr 7;: