A Pilot Study on Continuous Infusion of 4% Albumin in Critically Ill Patients: Impact on Nosocomial Infection via a Reduction Mechanism for Oxidized Substrates.
Fiche publication
Date publication
septembre 2019
Journal
Critical care explorations
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MEYER Nicolas, Pr SCHAAF Pierre
Tous les auteurs :
Schneider F, Dureau AF, Hellé S, Betscha C, Senger B, Cremel G, Boulmedais F, Strub JM, Corti A, Meyer N, Guillot M, Schaaf P, Metz-Boutigue MH
Lien Pubmed
Résumé
Care-related infections affect up to 11% of ICU patients. Running therapeutic albumin is sometimes associated to less infection: whether a specific method of its infusion is of any interest to modulate innate defense is unknown. Our objectives were: 1) to test whether the method for albumin infusion is important to prevent care-related infections and 2) to analyze in vitro the antioxidative role of albumin on host defense proteins during shock (using vasostatin-I as an example).
Mots clés
antimicrobial peptides, chromogranin A, critical care, nosocomial infections, protein-protein interaction, therapeutic albumin
Référence
Crit Care Explor. 2019 Sep;1(9):e0044