Herpes simplex virus 2 hepatitis in a lung transplant recipient: a diagnostic challenge.
Fiche publication
Date publication
décembre 2015
Journal
Transplant infectious disease : an official journal of the Transplantation Society
Auteurs
Membres identifiés du Cancéropôle Est :
Pr OHANA Mickaël
Tous les auteurs :
Hirschi S, Biondini D, Ohana M, Solis M, D'Urso A, Rosner V, Kessler R
Lien Pubmed
Résumé
Herpes simplex virus (HSV) hepatitis is a rare and serious complication in immunocompromised patients. We report the case of an HSV hepatitis occurring 4 years after lung transplantation in a cystic fibrosis patient. The presentation was nonspecific, mimicking acute cholecystitis; orogenital signs were absent. The diagnosis was made based on viral cultures performed during cholecystectomy and confirmed by blood quantitative polymerase chain reaction. Although the diagnosis and treatment were delayed, the patient fully recovered with acyclovir, reduced immunosuppression, and intravenous immunoglobulins. The diagnostic difficulties, prognostic factors, and treatments of this infection are discussed.
Mots clés
Acyclovir, therapeutic use, Adult, Antiviral Agents, therapeutic use, Female, Hepatitis, Viral, Human, diagnosis, Herpesvirus 2, Human, isolation & purification, Humans, Immunocompromised Host, Immunoglobulins, Intravenous, therapeutic use, Lung Transplantation, adverse effects
Référence
Transpl Infect Dis. 2015 Dec;17(6):904-8