EpiBrainRad: an epidemiologic study of the neurotoxicity induced by radiotherapy in high grade glioma patients.
Fiche publication
Date publication
décembre 2015
Journal
BMC neurology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NOEL Georges
Tous les auteurs :
Durand T, Jacob S, Lebouil L, Douzane H, Lestaevel P, Rahimian A, Psimaras D, Feuvret L, Leclercq D, Brochet B, Tamarat R, Milliat F, Benderitter M, Vayatis N, Noël G, Hoang-Xuan K, Delattre JY, Ricard D, Bernier MO
Lien Pubmed
Résumé
Radiotherapy is one of the most important treatments of primary and metastatic brain tumors. Unfortunately, it can involve moderate to severe complications among which leukoencephalopathy is very frequent and implies cognitive deficits such as memory, attention and executive dysfunctions. However, the incidence of this complication is not well established and the risk factors and process are poorly understood. The main objective of the study is to improve knowledge on radio-induced leukoencephalopathy based on pluridisciplinar approaches combining cognitive, biologic, imagery and dosimetric investigations.
Mots clés
Adult, Antineoplastic Agents, Alkylating, therapeutic use, Brain Neoplasms, therapy, Chemotherapy, Adjuvant, Cognition Disorders, diagnosis, Dacarbazine, analogs & derivatives, Early Diagnosis, Female, Follow-Up Studies, Glioma, therapy, Humans, Leukoencephalopathies, diagnosis, Male, Prospective Studies, Radiotherapy, adverse effects
Référence
BMC Neurol. 2015 Dec;15:261