Astrocyte Transcriptome from the Mecp2(308)-Truncated Mouse Model of Rett Syndrome.
Fiche publication
Date publication
décembre 2015
Journal
Neuromolecular medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHELLY Jamel
Tous les auteurs :
Delépine C, Nectoux J, Letourneur F, Baud V, Chelly J, Billuart P, Bienvenu T
Lien Pubmed
Résumé
Mutations in the gene encoding the transcriptional modulator methyl-CpG binding protein 2 (MeCP2) are responsible for the neurodevelopmental disorder Rett syndrome which is one of the most frequent sources of intellectual disability in women. Recent studies showed that loss of Mecp2 in astrocytes contributes to Rett-like symptoms and restoration of Mecp2 can rescue some of these defects. The goal of this work is to compare gene expression profiles of wild-type and mutant astrocytes from Mecp2(308/y) mice (B6.129S-MeCP2
Mots clés
Acute-Phase Proteins, secretion, Animals, Astrocytes, metabolism, COUP Transcription Factor II, biosynthesis, Cells, Cultured, Cerebral Cortex, pathology, Chromogranin B, secretion, Disease Models, Animal, Female, Gene Expression Profiling, Genome-Wide Association Study, Lipocalin-2, Lipocalins, secretion, Male, Methyl-CpG-Binding Protein 2, deficiency, Mice, Mice, Inbred Strains, NF-kappa B, metabolism, Nerve Tissue Proteins, biosynthesis, Oligonucleotide Array Sequence Analysis, Oncogene Proteins, secretion, RNA Interference, Real-Time Polymerase Chain Reaction, Reproducibility of Results, Rett Syndrome, genetics, Transcriptome
Référence
Neuromolecular Med.. 2015 Dec;17(4):353-63