Azacalixphyrins as NIR photoacoustic contrast agents.
Fiche publication
Date publication
octobre 2018
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ELHABIRI Mourad
Tous les auteurs :
Lavaud L, Pascal S, Metwally K, Gasteau D, Da Silva A, Chen Z, Elhabiri M, Canard G, Jacquemin D, Siri O
Lien Pubmed
Résumé
Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N-alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800-1000 nm range.
Référence
Chem. Commun. (Camb.). 2018 Oct 30;54(87):12365-12368