Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.
Fiche publication
Date publication
mai 2015
Journal
Antioxidants & redox signaling
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DAVIOUD-CHARVET Elisabeth , Dr ELHABIRI Mourad
Tous les auteurs :
Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E
Lien Pubmed
Résumé
Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum were shown to protect G6PD-deficient populations from severe malaria. Here, we investigated the mechanism of a novel antimalarial series, namely 3-[substituted-benzyl]-menadiones, to understand whether these NADPH-consuming redox-cyclers, which induce oxidative stress, mimic the natural protection of G6PD deficiency.
Mots clés
Antimalarials, chemistry, Benzyl Compounds, chemistry, Cell Line, Erythrocytes, drug effects, Glucosephosphate Dehydrogenase Deficiency, blood, Glutathione, metabolism, Humans, Malaria, prevention & control, Male, NADP, metabolism, Oxidative Stress, Reactive Oxygen Species, metabolism, Structure-Activity Relationship, Vitamin K 3, chemistry
Référence
Antioxid. Redox Signal.. 2015 May 20;22(15):1337-51