Low Z target switching to increase tumor endothelial cell dose enhancement during gold nanoparticle-aided radiation therapy.
Fiche publication
Date publication
janvier 2016
Journal
Medical physics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DETAPPE Alexandre
Tous les auteurs :
Berbeco RI, Detappe A, Tsiamas P, Parsons D, Yewondwossen M, Robar J
Lien Pubmed
Résumé
Previous studies have introduced gold nanoparticles as vascular-disrupting agents during radiation therapy. Crucial to this concept is the low energy photon content of the therapy radiation beam. The authors introduce a new mode of delivery including a linear accelerator target that can toggle between low Z and high Z targets during beam delivery. In this study, the authors examine the potential increase in tumor blood vessel endothelial cell radiation dose enhancement with the low Z target.
Mots clés
Endothelial Cells, drug effects, Gold, chemistry, Humans, Metal Nanoparticles, Monte Carlo Method, Particle Accelerators, Photons, therapeutic use, Radiation Dosage, Radiotherapy Dosage, Radiotherapy, Computer-Assisted, instrumentation
Référence
Med Phys. 2016 Jan;43(1):436