Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.
Fiche publication
Date publication
avril 2010
Journal
Retrovirology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HERBEIN Georges, Pr ROHR Olivier
Tous les auteurs :
Le Douce V, Herbein G, Rohr O, Schwartz C
Lien Pubmed
Résumé
The introduction of the highly active antiretroviral therapy (HAART) has greatly improved survival. However, these treatments fail to definitively cure the patients and unveil the presence of quiescent HIV-1 reservoirs like cells from monocyte-macrophage lineage. A purge, or at least a significant reduction of these long lived HIV-1 reservoirs will be needed to raise the hope of the viral eradication. This review focuses on the molecular mechanisms responsible for viral persistence in cells of the monocyte-macrophage lineage. Controversy on latency and/or cryptic chronic replication will be specifically evoked. In addition, since HIV-1 infected monocyte-macrophage cells appear to be more resistant to apoptosis, this obstacle to the viral eradication will be discussed. Understanding the intimate mechanisms of HIV-1 persistence is a prerequisite to devise new and original therapies aiming to achieve viral eradication.
Mots clés
HIV-1, growth & development, Humans, Macrophages, virology, Monocytes, virology, Virus Latency, Virus Replication
Référence
Retrovirology. 2010 Apr;7:32